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Impact of CHK1i on CDK1/2 substrates. MDA-MB-231 cells were incubated with 50 nM gemcitabine for 18 h, removed, and CHK1i added for another 6 h. Cells were lysed and analyzed by Western blotting for the indicated antigens. For the pTPXK blot, the size of molecular weight markers are shown on the left. The molecular weights on the right refer to the target proteins previously observed, together with the concentration of CVT-313 that inhibited their appearance by 50%.20
