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. 2021 Apr 8;21:199. doi: 10.1186/s12935-021-01866-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Upregulation of FZD2 in BC tissues is correlated with poor prognosis. a Data obtained from TCGA database revealed the FZD2 expression in different types of cancer tissues. b DMFS of BC patients with high or low level of FZD2 were analyzed by generating KM plots based on publicly available microarray data. c Representative images of FZD2 upregulation in BC tissues were generated from the ONCOMINE database. d qRT-PCR detected the mRNA level of FZD2 in 42 BC tissues and adjacent normal tissues. e Western blot analysis of FZD2 protein in BC tissues with adjacent normal tissues as controls. f Representative images of FZD2 expression in BC tissues were obtained using IHC (Original magnification, × 400, scale bar, 100 μm). g OS (left panel) and DMFS (right panel) in BC patients were analyzed by KM method. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 was a symbol of statistical significance. TCGA, the cancer genome atlas; FZD2, frizzled class receptor 2; BC, breast cancer; KM, Kaplan–Meier; OS, overall survival; RFS, recurrence-free survival; DMFS, distant metastasis free survival