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. 2021 Apr 8;21:198. doi: 10.1186/s12935-021-01856-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Quizartinib and pexidartinib are effective inhibitors of FLT-dependent AML cell lines. The viabilities (normalised with respect to control, i.e., 0.25% DMSO) of MOLM-14 (a, c) and MV4-11 (b, d) are shown as the cells are treated by increasing concentrations of quizartinib (a, b) and pexidartinib (c, d). Each measurement was carried out in triplicate after 48 h of growth in presence of an inhibitor in a given concentration. Cell viabilities are estimated from an MTS assay (see “Methods” section for details)