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. 2021 Apr 8;21:198. doi: 10.1186/s12935-021-01856-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Simulations of treatment corresponding to the rotation protocols. The top panel is a violin plot showing the probability densities of WT $_{1 / 2}$ values from the simulations (Y-axis: WT $_{1 / 2}$ , X-axis: probability densities for each protocol). The horizontal lines show minimum, median and maximum values. The bottom panel shows the median WT $_{1 / 2}$ . Higher WT $_{1 / 2}$ values implicate that the tumour is sensitive to the treatment for a longer time. The figure was obtained by simulations of the mutational landscape using the wollsey stochastic evolution simulator [6]