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Fold-IC50 values for FLT3 mutations relative to FLT3-ITD
| Mutation | Fold IC50 quizartinib | Fold IC50 pexidartinib |
|---|---|---|
| None | 1 | 1 |
| F691L | 329 | 3 |
| D835A | 10 | 18 |
| D835E | 6 | 9 |
| D835F | 1474 | 415 |
| D835G | 10 | 13 |
| D835H | 45 | 40 |
| D835I | 718 | 1937 |
| D835N | 7 | 10 |
| D835V | 563 | 320 |
| D835Y | 183 | 206 |
| D835Del | 320 | 121 |
| D839G | 6 | 27 |
| Y842C | 106 | 48 |
| Y842H | 58 | 49 |
