Table 1. Pharmacokinetics of Uptake and Clearance Rate Constants for Each Compound.
| compound | organ | uptake rate constant, λ (%IA/g/h) | fast clearance rate constant, λ1 (%IA/g/h) | slow clearance rate constant, λ2 (%IA/g/h) |
|---|---|---|---|---|
| 225Ac-DOTA-MC1RL | blood | 0.00756 | 1.89 | |
| kidney | 3.98 | 0.0361 | 0.0275 | |
| liver | 30.1 | 63.8 | 0.00737 | |
| 225Ac-DOTA-Ahx-MC1RL | blood | 0.507 | 0.0125 | |
| kidney | 5.63 | 0.0605 | 0.00514 | |
| liver | 17.3 | 0.0662 | 0.00319 | |
| 225Ac-DOTA-DLDL-MC1RL | blood | 1.87 | 0.00577 | |
| kidney | 179 | 0.0229 | –0.0109 | |
| liver | 55.9 | 0.00511 | –0.0323 | |
| 225Ac-DOTA-DGDL-MC1RL | blood | 0.0198 | 2.00 | |
| kidney | 44.1 | 0.0117 | –0.0118 | |
| liver | 8.97 | 0.0412 | 0.00360 |