Table 3. Relationship of log D7.4 with Kidney Uptake, Radiation Doses, and Toxicity.
| kidneyb |
||||||
|---|---|---|---|---|---|---|
| probability
of toxicity at 148 kBq injected activity |
||||||
| linker | log D7.4a | uptake rate constant, λ (%IA/g/h) | total absorbed dose (Gy/kBq) | pathology | BUN | weight loss |
| no linker | –2.41 ± 0.26 | 3.985 | 0.5628 | 0.00 | 0.04 | 0.01 |
| Ahx | –2.59 ± 0.20 | 5.625 | 0.1366 | 0.23 | 0.10 | 0.10 |
| DLDL | –3.49 ± 0.27 | 178.5 | 1.5980 | 0.95 | 1.00 | 1.00 |
| DGDL | –3.88 ± 0.17 | 44.08 | 0.9200 | 0.95 | 0.94 | 0.99 |
a
Determined using the La3+ chelate.
b
Determined using the 225Ac chelate.