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. 2021 Mar 16;4(2):858–869. doi: 10.1021/acsptsci.1c00013

Figure 3.

Figure 3

(A) Time course of changes in accelerating rotarod performance at different ages. Note that MitoPark mice treated with PT320 have values almost equal to those of WT animals, whereas untreated MitoPark mice are significantly impaired at later ages (red dashed circle). Two-way analysis of variance (ANOVA) followed by a Bonferroni post hoc test for multiple comparisons. WT male compared to MitoPark (MP) male: #, p < 0.05; ##, p < 0.01; and ###, p < 0.001. MP male compared to PT320-treated MP male: *, p < 0.05; **, p < 0.01. (B) Accelerating rotarod performance in 20, 22, and 24 week old MP mice. Unpaired t-test: *, p < 0.05, and **, p < 0.01.