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. 2021 Mar 16;4(2):858–869. doi: 10.1021/acsptsci.1c00013

Figure 4.

Figure 4

(A) DA release in striatum, studied with FSCV in MitoPark and WT mice at 8 weeks, an age when there is little change in striatal DA, at 12 and 16 weeks, where the changes in DA are significant, and at 22 weeks when changes in behavior and loss of nigrostriatal innervation are still more pronounced. One-way analysis of variance (ANOVA) followed by Bonferroni post hoc test for multiple comparisons. MP vs MP+PT320: ***, p < 0.001; WT vs MP: ##, p < 0.01, and ###, p < 0.001; WT vs MP+PT320: $, p < 0.05, and $$$, p < 0.001. (B) DA release in nucleus accumbens (NAc) measured by FSCV at 8, 12, 16, and 22 weeks old MitoPark mice. The PT320-induced changes in DA release at 12 and 16 weeks are less than in striatum and are in accord with smaller reductions in the DA input to NAc in MitoPark mice at this age, compared with striatal DA input. One-way analysis of variance (ANOVA) followed by a Bonferroni post hoc test for multiple comparisons. *, p < 0.05. Unpaired t-test analysis.