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. 2021 Mar 16;4(2):858–869. doi: 10.1021/acsptsci.1c00013

Figure 5.

Figure 5

(A) DA Transporter (DAT) expression as a marker of striatal DA fibers in 8, 12, 16, and 20 week old MitoPark animals using PET scans. Although values in the PT320-treated MitoPark mice are less than in WT mice at these ages, they still are significantly greater than the values in untreated MitoPark mice. One-way analysis of variance (ANOVA) followed by a Bonferroni post hoc test for multiple comparisons: *, p < 0.05, and **, p < 0.01. (B) Changes in TH expression in 8, 12, 16, and 22 week old MitoPark mice. Again, we note little change at 8 weeks but major changes with PT320 in 12, 16, and 22 week old MitoPark mice, as compared to untreated MitoPark animals. Unpaired t-test analysis: ###, p < 0.001; *, p < 0.05; **, p < 0.01; and ***, p < 0.001. One-way analysis of variance (ANOVA) followed by Bonferroni post hoc test for multiple comparisons. MP vs MP+PT320: *p < 0.05, **p < 0.01; ***, p < 0.001. WT vs MP: ##, p < 0.01, and ###, p < 0.001. WT vs MP+PT320: $$, p < 0.01, and $$$, p < 0.001.