Table 3. Study Design and Quality Appraisal.
| quality
appraisal |
||||||
|---|---|---|---|---|---|---|
| study design | 1 | 2 | 3 | 4 | 5 | number of studies |
| case report/series | 36 | 36 | ||||
| cross-sectional | 17 | 17 | ||||
| longitudinal | 4 | 4 | ||||
| open-label trial | 4 | 4 | ||||
| randomized controlled trial | 3 | 3 | ||||
| total | 3 | 25 | 36 | 64 | ||
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