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. 2021 Mar 3;4(2):780–789. doi: 10.1021/acsptsci.0c00218

Table 2. Inhibition of Lead Compounds against IP6K1, IP6K2, IP6K3, and IPMK.

  LI-2124 LI-2242 LI-2260 LI-2172 LI-2180 LI-2178
IP6K1 IC50 (nM) 2.5 31 33 27 57 800
IP6K2 IC50 (nM) 3 42 31.7 25 58.5 1170
IP6K3 IC50 (nM) 1 8.7 9 8 135 N/A
IPMK IC50 (nM) 205 1944 1124 156 13163 5565
IPMK/IP6K1 IC50 ratio 82 63 34 6 231 7