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. 2021 Mar 15;12:604713. doi: 10.3389/fphar.2021.604713

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Copyright © 2021 Paci, Koivumäki, Lu, Gallacher, Passini and Rodriguez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ion currents underlying the steady-state action potentials in the Paci2020 (blue), Kernik2019 (green) and Koivumäki2018 (red) models. (A and H) Membrane potential. (B) Fast Na⁺ current (I_Na). (C) L-type Ca²⁺ current (I_CaL). (D) Na⁺-Ca²⁺ exchanger (I_NCX). (E) Inward rectifying K⁺ current (I_K1). (F) Na⁺-K⁺ pump (I_NaK). (G) Ca²⁺ release from sarcoplasmic reticulum (J_RyR). (I) Funny current (I_f). (J) Transient outward K⁺ current (I_to). (K) Rapid delayed rectifying K⁺ current (I_Kr). (L) Slow delayed rectifying K⁺ current (I_Ks). (M) Sarcolemma Ca²⁺ pump (I_pCa). (N) SERCA pump (J_SERCA).