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Illustrative action potential (black) and Ca2+ transient (blue) arrhythmic rhythms, abnormalities and the cessation of spontaneous activity produced by the three models. Paci2020: repolarization failure (A), quiescence (D). Koivumäki2018: early after-depolarizations (B) and residual activity (E). Kernik2019: repolarization failure (C) and irregular rhythm (F). The drug concentrations are reported as C1, C2 and C3, consistently with Supplementary Table S2.
