TABLE 1.
Summary of the compartments and the ion currents and fluxes included in the three models.
| Paci2020 | Koivumäki2018 | Kernik2019 | |
|---|---|---|---|
| Compartments | 2 | 61 | 2 |
| INa | HH | HH | HH |
| INaL | HH | — | — |
| If | HH | HH | HH |
| ICaL Ca2+ | HH, GHK | HH | HH, GHK |
| ICaL Na+ | — | — | HH, GHK |
| ICaL K+ | — | — | HH, GHK |
| ICaT | — | — | HH |
| IKr | HH | HH | HH |
| IKs | HH | HH | HH |
| IK1 | HH | HH | HH |
| Ito | HH | HH | HH |
| INCX | TT | TT | TT |
| INaK | TT | TT | TT |
| IpCa | TT | TT | TT |
| IbNa | HH, R | HH, R | HH, R |
| IbCa | HH, R | HH, R | HH, R |
| JRyR | HH, R | M 2 | M 1 |
| JSERCA | TT | TT | TT |
| Jleak | HH, R | HH, R | HH, R |
| JIP3 | — | M 3 | — |
We reported the modeling paradigm for each ion current/flux: Hodgkin and Huxley (HH), Hodgkin and Huxley as resistive current/flux (HH,R), Hodgkin and Huxley gates with Goldman-Hodgkin-Katz driving force (HH,GHK), Markov (M), based on the TenTusscher2004 model (ten Tusscher et al., 2004) (TT).