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. 2021 Mar 29;4(2):966–979. doi: 10.1021/acsptsci.1c00041

Figure 1.

Figure 1

In vitro characteristics of the study compounds FXRA/sEHi DM and sEHi MH. (a) Effects of the study compounds on expression levels of selected FXR-regulated genes in human hepatocytes (HepG2). Data are mean ± S.E.M. fold mRNA induction compared to DMSO (0.1%) treated cells, n = 5. *, p < 0.05; **, p < 0.01; and ***, p < 0.001 (t-test) vs DMSO (0.1%). CDCA vs CDCA+MH were not statistically different. (b) Selectivity profiles of the study compounds over relevant members of the nuclear receptor family. The heat map shows mean relative activation compared to the respective reference agonist, n = 5. (c) Microsomal stability of the study compounds. Data are mean ± S.E.M. remaining parent compound, n = 5.