Table 8. Crystal Structures of the Human SHMTs.

protein	variant	ligands	macromolecule	method	resolution	PDB ID	refs
SHMT1	WT	PLP	NAa	X-ray	2.65 Å	1BJ4	(159)
	H135N, R137A, E168N	PLP	NA	X-ray	3.60 Å	6FL5	(160)
SHMT2	WT	NA	NA	X-ray	2.04 Å	6DK3	TBPb
	A264T	NA	BRISC-complex	cryo-EM	3.90 Å	6H3C	(128)
	WT	NA	BRISC-complex	cryo-EM	3.80 Å	6R8F	(129)
	WT	PLP, pemetrexed	NA	X-ray	2.28 Å	6QVL	(152)
	WT	PLP, lometrexol	NA	X-ray	2.32 Å	6QVG
	WT	PLP	NA	X-ray	2.60 Å	4PVF	(161)
	WT	PLP, compound 2	NA	X-ray	2.47 Å	5V7I	(143)
	K74R, A264T	NA	NA	X-ray	2.85 Å	5X3V	TBP

^aNA, not applicable.

^bTBP, to be published.