Table 1. Physicochemical and Druglike Properties of FR and YM.

		FR	YM
exact mass (Da)		1001.53	959.49
heavy atoma count		71	68
number of defined stereocenters		11	11
specific rotationb ([α]D20)		–54.8	–64.5
rotatable bond count		15	13
polar surface area		285 Å2	285 Å2
calculated logP valuec		1.86	1.37
number of hydrogen bond donors		5	5
number of hydrogen bond acceptors		22	22
solubility in phosphate-buffered saline containing 1% dimethyl sulfoxide (DMSO)d		189 ± 17 μM	88 ± 12 μM
plasma protein binding		35%	79%
residence time of tritiated derivative at human platelet membranese	at 37 °C	92.1 min	3.8 min
	at 21 °C	343.3 min	13.4 min

^aNon-hydrogen atoms

^bSynthetic compounds, measured in methanol, c (FR) 0.073 g/mL, c (YM) 0.11 g/mL.²⁴

^cCalculated logP values were obtained using the StarDrop program.

^dValues represent means ± SD (n = 3).

^eReference (27).