Table 2. Apparent Transport Rates (Papp) of YM-254890, FR900359, and Control Compounds in Caco-2 Cells.
| compound | direction | Papp·10-6 (cm/s)a | ratio (b-a/a-b)b | permeability |
|---|---|---|---|---|
| YM-254890 | a-b | 0.1 ± 0.0 | 182 | low |
| b-a | 20.9 ± 2.8 | |||
| FR900359 | a-b | 0.4 ± 0.0 | 29 | low |
| b-a | 11.5 ± 0.4 | |||
| testosterone | a-b | 19.2 ± 1.0 | 2 | high |
| b-a | 39.7 ± 5.2 | |||
| erythromycin | a-b | 0.1 ± 0.1 | 106 | low |
| b-a | 11.2 ± 0.4 | |||
| atenolol | a-b | 0.4 ± 0.0 | 7 | low |
| b-a | 2.8 ± 0.4 |
a
Apparent permeability (values represent means ± SD, n = 3).
b
High ratio indicates efflux by transporter proteins.