Table 3. Metabolic Stability of FR and YM in Human and Mouse Liver Microsomes.
| CLint,app (μL/min/mg protein) |
t1/2 (min) |
|||
|---|---|---|---|---|
| human | mouse | human | mouse | |
| FR900359 | 171.0 | 237.4 | 8.1 | 5.8 |
| YM-254890 | 50.8 | 82.2 | 27.3 | 16.9 |
| verapamil (control) | 134.6 | 335.7 | 10.3 | 4.1 |
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