Table 2.
Changes in Hemodynamic and Metabolic Parameters at 6 Months
| Metoprolol (n=32) | Nebivolol (n=29) | Between‐Group P Value | |
|---|---|---|---|
| Heart rate, beats per min | |||
| Baseline | 74.5±12.9 | 76.5±10.1 | .63 |
| 26 weeks | 66.3±12.8 | 65.1±10.4 | |
| Within‐group P value | <.001 | <.001 | |
| Brachial SBP, mm Hg | |||
| Baseline | 139.4±9.1 | 139.6±9.1 | .67 |
| 26 weeks | 131.8±12 | 132.8±10.7 | |
| Within‐group P value | .010 | .002 | |
| Brachial DBP, mm Hg | |||
| Baseline | 78.9±8.4 | 78.7±7.6 | .33 |
| 26 weeks | 76.2±8 | 74.4±7.9 | |
| Within‐group P value | .031 | .007 | |
| Aortic SBP, mm Hg | |||
| Baseline | 127.8±8.8 | 125.3±8.0 | .34 |
| 26 weeks | 123.8±11.1 | 121.6±8.2 | |
| Within‐group P value | .1 | .025 | |
| Aortic DBP, mm Hg | |||
| Baseline | 79.8±8.4 | 78.9±6.9 | .3 |
| 26 weeks | 77.4±8.4 | 74.9±8.1 | |
| Within‐group P value | .039 | .013 | |
| Pulse pressure amplification | |||
| Baseline | 0.79±0.09 | 0.77±0.08 | .1 |
| 26 weeks | 0.85±0.12 | 0.83±0.09 | |
| Within‐group P value | .02 | .003 | |
| Augmentation index at 75 beats per min | |||
| Baseline | 26.2±8.3 | 22.0±7.1 | .19 |
| 26 weeks | 24.6±6.7 | 22.1±7.4 | |
| Within‐group P value | .280 | .9 | |
| Pulse wave velocity | |||
| Baseline | 6.52±1.2 | 6.48±0.8 | .86 |
| 26 weeks | 6.4±1.3 | 6.3±0.9 | |
| Within‐group P value | .55 | .55 | |
| Hemoglobin A1c | |||
| Baseline | 6.55±0.81 | 6.72±0.81 | .9 |
| 26 weeks | 7.0±1.6 | 6.72±0.84 | |
| Within‐group P value | .007 | .39 | |
| Total cholesterol | |||
| Baseline | 165.34±31.3 | 169.8±40.8 | .894 |
| 26 weeks | 166.65±33.2 | 167±30.9 | |
| Within‐group P value | .62 | .83 | |
| Estimated GFR | |||
| Baseline | 80.4±23.5 | 73.8±18.9 | .55 |
| 26 weeks | 74.1±22.3 | 75.0±21.3 | |
| Within‐group P value | .008 | .63 | |
Abbreviations: DBP, diastolic blood pressure; GFR, glomerular filtration rate; SBP, systolic blood pressure. Data are expressed as means and percentage±standard deviation.