Table 1.
Baseline Characteristics of the Study Population
| Parameter | Group | P Valuea | ||||
|---|---|---|---|---|---|---|
| APA (n=103) | UNAH (n=52) | IHA (n=74) | PA (n=229) | EH (n=100) | ||
| Age, y | 40.3±8.6 | 41.4±7.6 | 43.5±9.0 | 42.0±8.7 | 43.5±14.0 | .211 |
| Sex distribution, female/male | 44/59 | 27/25 | 46/28 | 110/112 | 45/55 | .156 |
| SBP, mm Hg | 153.1±24.2 | 154.0±19.2 | 154.0±19.6 | 153.7±21.2 | 146.3±17.2 | .025 |
| DBP, mm Hg | 96.5±13.6 | 93.2±13.5 | 93.2±12.8 | 94.3±13.2 | 89.5±11.9 | .021 |
| Supine aldosterone, ng/L | 594.9±365.2c,e | 392.6±180.4 | 292.8±324.5 | 373.8±339.0 | 144.4±88.2 | .000 |
| Upright aldosterone, ng/L | 531.8±384.6c | 521.4±442.4c | 323.3±232.8 | 401.9±318.8 | 193.1±100.8 | .000 |
| Supine PRA, ng/mL/h | 0.07±0.12c | 0.10±0.19 | 0.15±0.25 | 0.11±0.21 | 1.47±1.13 | .000 |
| Upright PRA, ng/mL/h | 0.25±0.32 | 0.18±0.22d | 0.31±0.39 | 0.26±0.35 | 2.90±1.39 | .000 |
| Urinary aldosterone excretion, µg/24 h | 26.65±17.67c | 25.16±19.34c | 15.21±10.72 | 21.23±16.05 | 8.15±6.57 | .000 |
| Plasma K+, mEq/L | 2.41±0.55c | 2.57±0.65c | 2.95±0.72 | 3.06±0.62 | 3.68±0.39 | .000 |
| Urinary potassium excretion, mmol/24 h | 48.07±30.24 | 52.65±28.66 | 49.61±30.90 | 49.63±30.27 | 41.32±13.11 | .071 |
Abbreviations: APA, aldosterone‐producing adenoma; DBP, diastolic blood pressure; EH, essential hypertension; IHA, idiopathic hyperaldosteronism; PA, primary aldosteronism; PRA, plasma renin activity; SBP, systolic blood pressure; UNAH, unilateral nodular adrenal hyperplasia. Data are expressed as mean±standard deviation or distributions. P a=unpaired t test between the PA and EH groups. Compared with the IHA group. b P<.001. c P<.05. Compared with the UNAH group. e P<.05.