Table 1.
Intervention, Characteristics, and Effects on BP in Individual Studies
| Study | Up‐titration of Antihyper‐ tensives | Statin, mg/d | Follow‐ Up, mo | HTN/ Hyperlipidemia/ Diabetes | Age Treatment/ Control, SD | Treatment Group Baseline SBP/ DBP, mm Hg | Treatment Group Follow‐Up SBP/DBP, mm Hg | Control Group Baseline SBP/ DBP, mm Hg | Control Group Follow Up SBP/ DBP, mm Hg |
|---|---|---|---|---|---|---|---|---|---|
| Lavallee and colleagues7 | + | Atorvastatin (80) | 3 | +/+/− | 61/60 | 132.7 (14.6)/ 78 (8.3) | −3.9 (2.1)/ −2.8 (1.4) | 133.7 (12.8)/ 78.1 (7.7) | −0.8 (2.24)/ −1.4 (1.5) |
| Mancia and colleagues8 | − | Pravastatin (40) | 31 | +/+/− | 58.5/58.3 | 159.6 (8.9)/ 98.3 (4.1) | −19.2 (1.94)/ −12.4 (1.55) | 160 (9.1)/ 98.3 (4.4) | −18.1 (1.94)/ −12.8 (1.55 |
| Williams and colleagues10 | + | Atorvastatin (10) | 40 | +/+/− | 62.6/62.9 | 159.6 (16.7)/ 92.5 (9.7) | 133.9 (0.6)/ 79.1 (0.4) | 160.3 (17.5)/ 92.9 (9.2) | 133.8 (0.6)/ 79 (0.4) |
| Manisty and colleagues9 | + | Atorvastatin (10) | 12 | +/+/− | 64/84 | 158 (20)/93 (10) | 141 (11)/81 (8) | 164 (20)/94 (10) | 142 (12)/81 (7) |
| Orr and colleagues11 | − | Atorvastatin (80) | 3 | −/+/− | 53/55 | 129 (4)/74 (2) | 124 (4)/73 (3) | 127 (4)/75 (2) | 124 (4)/75 (2) |
| Ge and colleagues37 | − | Atorvastatin (20) | 4 | +/+/− | 64/65 | 164.3 (14.8)/ 106.4 (9.2) | 123.2 (12.4)/ 82.5 (7.8) | 162.8 (13.4)/ 105.2 (8.6) | 136.7 (11.2) 91 (7.32) |
| Kuklinska and colleagues16 | − | Atorvastatin (80) | 3 | +/+/− | 53 | 129 (11)/76 (9) | 123.3 (8.9)/ 72.1 (8.6) | 129.5 (13)/ 74 (7.6) | 128.5 (9.7)/ 74 (7.6) |
| Grimm and colleagues14 | − | Atorvastatin (20) | 1.5 | +/+/− | 56.5/55.5 | 132.3 (11.3)/ 81 (9.5) | −4 (1)/ −1.7 (0.8) | 132.9 (12.3)/ 81.9 (8.2) | −1 (1.17)/ −1.1 (0.7) |
| Koh and colleagues12 | − | Atorvastatin (20) | 2 | +/+/− | 53 (2) | 157 (1)/96 (1) | 138 (2)/85 (1) | 156 (2)/95 (1) | 139 (1)/85 (1) |
| Tonelli and colleagues19 | + | Pravastatin (40) | 24 | −/+/− | 58.5/58.7 | 128.7 (18.4)/78.5 (10.2) | 0.7 (0.4)/0.2 | 129 (17.8)/ 78.6 (10.1) | −0.2 (0.3)/ −0.4 (0.3) |
| Ichihara and colleagues39 | + | Pravastatin (10) | 12 | +/+/− | 60/60 | 142 (7)/84 (3) | 140 (5)/86 (2) | 142 (6)/89 (4) | 138 (10)/90 (3) |
| Simvastatin (5) | 12 | 60 | 145 (4)/88 (2) | 142 (4)/86 (2) | |||||
| Fluvastatin (20) | 12 | 60 | 142 (6)/84 (3) | 141 (4)/85 (2) | |||||
| Kushiro and colleagues40 | + | Pravastatin | 60 | +/+/− | 60/60 | 140.9 (16)/ 82.9 (10) | 138.6 (16)/ 80.3 (10) | 141 (15)/83 (10) | 139.1 (15)/ 81.3 (10) |
| Terzoli and colleagues18 | + | Simvastatin, Pravastatin, Atorvastatin | 2 | +/+/− | 62.7 (10.3)/ 62.7 (10.3) | 149.8 (15.9)/ 87 (9.3) | 143.6 (11.3)/ 83.7 (10.1) | 152.2 (12.4)/ 85.3 (5.8) | 150.6 (11.6)/ 87.4 (6.4) |
| 135.2 (14.6)/ 78.7 (10.7) | 132.8 (13.7)/ 77.6 (9.5) | 140.3 (11)/ 82.6 (4.6) | 138.7 (10.6)/ 83.7 (6.4) | ||||||
| Collins and colleagues49 | + | Simvastatin (40) | 56 | +/+/− | 65.5 (7.8)/ 65.1 (8.2) | −7.6 (27.5)/−4.5 (15.1) | −7.1 (28.9)/ −4.6 (14.1) | ||
| Sposito and colleagues17 | + | Pravastatin, Lovastatin | 4 | +/+/− | 52 (3)/53 (3) | 153 (9)/100 (3) | 130 (5)/81 (4) | 149 (8)/102 (2) | 137 (6)/87 (8) |
| Athyros and colleagues22 | − | Various Statins (various doses) | 36 | +/+/− | 58 (11)/58 (14) | 123 (14)/74 (8) | 122 (12)/74 (8) | 125 (16)/75 (9) | 122 (13)/73 (8) |
| Cohn and colleagues34 | + | Atorvastatin (10) | 2 | +/−/− | 54.7 (8.9)/ 55.3 (9.3) | 146.7 (11.1)/91.8 (7.2) | −7 (2)/−4.2 (1) | 147 (11)/93 (5.3) | −5 (2)/−3.4 (0.8) |
| Balletshoffer and colleagues15 | − | Cerivastatin (0.8) | 3 | +/−/+ | 59 (8)/59 (8) | 148 (22)/86 9) | 141 (22)/82 (12) | 151 (14)/85 (11) | 157 (16)/88 (11) |
| Cerivastin (0.2) | 59 (8)/59 (8) | 141 (22)/82 (12) | 149 (26)/86 (11) | ||||||
| Lewandowski and colleagues45 | − | Simvastatin (40) | 2 | +/+/− | 38.7 (10)/ 38.7 (10) | 142 (11.8)/91 (10.8) | 136 (9.5)/84 (9.8) | 136 (9.5)/ 86 (11) | 131 (12.4)/82 (7.5) |
| Danaoglu and colleagues35 | − | Simvastatin (20) | 3 | +/+/− | 52 (3)/54 (4) | 160 (11)/99 (9) | 122 (9)/76 (6) | 158 (14)/ 104 (10) | 126 (19)/82 (8) |
| Derosa and colleagues27 | − | Fluvastatin (80) | 12 | −/+/− | 50.6 (9.4)/ 52.4 (10.2) | 133 (4)/86 (5) | 127 (5)/82 (3) | 132 (5)/84 (3) | 128 (3)/82 (2) |
| Fluvastatin (80) | 12 | 53.1 (10)/ 51.6 (8.3) | 132 (4)/85 (3) | 123 (4)/79 (2) | 131 (3)/85 (4) | 125 (3)/81 (2) | |||
| Fassett and colleagues36 | + | Atorvastatin (10) | 12 | +/+/− | 62.3 (16.3)/ 64.8 (15) | 147.6 (20.2)/75.8 (9.1) | −4.18 (8.35)/ −1.24 (5.22) | 148.3 (22.1)/ 79.3 (6.7) | −4.63 (8.98)/ −1.98 (3.51) |
| Glorioso and colleagues41 | − | Atorvastatin (20) | 4 | +/+/− | 53 (2)/53 (2) | 149 (6)/97 (2) | 140 (5)/90 (4) | 149 (6)/97 (2) | 147 (8)/94 (4) |
| Hjelstuen and colleagues38 | + | Fluvastatin (40) | 12 | +/+/− | 55.8 (7.9)/ 57.5 (9.2) | 141.8 (12.3)/90.5 (7.4) | −1.7 (14.25)/ 0.1 (9.1) | 140.4 (15.3)/ 88.6 (9) | −1.5 (7.68)/ −1.1 (7.68) |
| Su and colleagues46 | 0 | Pravastatin (10) | 6 | +/+/− | 61/64 | 175 (11)/105 (6) | 130 (9)/73 (6) | 174 (9)/104 (5) | 130 (8)/76 (7) |
| Teixeira and colleagues21 | + | Fluvastatin (20) | 12 | +/+/− | 51/51 | 139 (14)/87 (11) | 126 (12)/80 (7) | 138 (12)/86 (9) | 131 (11)/82 (8) |
| Sever and colleagues20 | − | Atorvastatin (10) | 36 | +/+/− | 63/63.3 | 164.3 (17.8)/95.1 (10.2) | 137.5 (17)/ 80.5 (9.5) | 164.7 (18.3)/ 95.1 (10.4) | 137.5 (16.8)/ 80.8 (9) |
| Atorvastatin (10) | 36 | +/+/− | 63.2/63 | 164.1 (17.7)/94.9 (10.4) | 140 (16.5)/ 82.5 (9.8) | 163.7 (17.7)/ 95 (10.1) | 140.5 (16.5)/ 82.6 (9.6) | ||
| Colomb and colleagues13 | − | Pravastatin (40) | 6 | −/−/− | 57.4/57.7 | 126.8/75.2 | −2.5 (21.12)/ −2.8 (17.61) | 126.5/74 | −1 (21.1)/ −0.4 (17.8) |
| Simvastatin (20) | 6 | 126.8/75.2 | −2.7 (21.05)/ −2.4 (17.2) | 0.2 (20.9)/ 0.6 (17.1) | |||||
| Lee and colleagues42 | − | Pravastatin (40) | 6 | +/−/− | 71/72 | 133 (16)/76 (10) | 130 (18)/79 (8) | 134 (15)/75 (9) | 132 (14)/79 (8) |
| Magen and colleagues43 | − | Atorvastatin (10) | 2 | +/+/− | 54.1/51.4 | 153 (4.8)/87.1 (6.7) | 136.9 (6.1)/7 8.3 (4.2) | 151.1 (7.4)/ 84.7 (5.9) | 150.9 (6.8)/ 83.2 (5.7) |
| Nakamura and colleagues25 | − | Cerivastatin (0.15) | 6 | −/−/+ | 58/55 | 122 (14)/78 (10) | 118 (16)/76 (8) | 124 (12)/76 (12) | 126 (12)/76 (10) |
| Olkinuora and colleagues44 | − | Simvastatin (10) | 3 | +/+/− | 61/62 | 156 (12)/93 (9) | 142 (10)/86 (8) | 161 (12)/95 (9) | 147 (15)/88 (9) |
| McDowell and colleagues29 | − | Simvastatin (40) | 3 | −/+/− | 18–70 | 133 (18.7)/80 (11.2) | 136 (18.7)/78 (11.2) | 130 (20.8)/76 (10.4) | 137 (17.3)/80 (7) |
| Hommel and colleagues30 | − | Simvastatin (20) | 3 | +/+/+ | 41/35 | 140 (18)/84 (11) | 135 (21)/82 (10) | 135 (19)/83 (11) | 138 (18)/86 (11) |
| Bak and colleagues26 | − | Pravastatin+diet 1 (20) | 6 | −/+/− | 55.3/54.6 | 133 (14.1)/83.1 (7.4) | 2.5 (16.1)/2 (7.14) | 134.4 (14.9)/82.9 (8) | 0.6 (18.6)/0.9 (9.1) |
| Pravastatin+diet 2 (20) | 55.6/54.6 | 137.5 (16.3)/85.4 (6.1) | −5.1 (18.21)/ −0.9 (8.9) | 137.4 (14.2)/84.1 (7.3) | −2.8 (15.7)/0.1 (7.65) | ||||
| Lee and colleagues28 | − | Pravastatin (20) | 6 | +/+/− | 52/50 | 121 (10)/70 (4) | 120 (11)/70 (6) | 117 (10)/69 (5) | 117 (8)/70 (4) |
| Hodis and colleagues48 | − | Lovastatin (80) | 48 | −/+/− | 37–67 | 124.6 (13.3)/80.5 (7.2) | 122.5 (11.9)/ 78.7 (6.7) | 122.2 (14)/79.6 (8.1) | 121.1 (12.6)/78.7 (7.6) |
| Borghi and colleagues23 | − | Simvastatin | 60 | +/+/− | 55.2 (10) | 118 (5)/78.5 (6) | 3.54 (6.14)/ −1.57 (4.7) | 119.3 (6)/79.3 (7) | 3.58 (6)/−1.98 (3.49) |
| Simvastatin | 60 | 59.9 (7) | 130.3 (1)/82 (8) | −6.5 (10.42)/ −3.28 (6.56) | 132.6 (3)/84.7 (6) | −.66 (9.78)/−1.7 (5.5) | |||
| Simvastatin | 60 | 61.2 (8) | 145.6 (6)/88.3 (8) | −11.64 (7.2)/ −5.3 (7.5) | 145.3 (4)/89.5 (7) | −2.9 (5.25/ −2.68 (6.5) | |||
| Simvastatin | 60 | 65.5 (8) | 164.7 (5)/97.2 (6) | −24.7 (7.2)/ −12.5 (7.5) | 166.8 (12)/95.6 (11) | −6.67 (11.2)/ −5/7 (9.7) | |||
| Fogari and colleagues24 | − | Atorvastatin (20) | 3 | +/+/+ | 58.7/58.7 | 160 (11)/98 (5) | 137 (8)/80 (4) | 160 (11)/98 (5) | 143 (8)/84 (4) |
| Kanaki and colleagues31 | − | Atorvastatin (10) | 6.5 | +/+/− | 59.7/58.8 | 146.7 (7.2)/92.2 (10.3) | 141.6 (7.3)/ 89.6 (9.2) | 147.5 (6.7)/91.2 (8.5) | 147.8 (6.8)/90.6 (8.9) |
Abbrevations: BP, blood pressure; DBP, diastolic blood pressure; HTN, hypertension; SBP, systolic blood pressure; SD, standard deviation.