Table 9.

Preventive medication against chronic migraine with recommended doses

Drug	Daily dose
Beta-blockers:
Metoprolol	50–200 mg
Propranolol	40–240 mg
Candesartancilexetil	16 (24–32) mg
Topiramate	50–100 (200) mg
Amitriptyline	10–100 mg
Botulinum type a toxin	155–195 units i.m. Every 12 weeks
CGRP-antibodies:
Erenumab	70–140 mg s.c. every 4 weeks
Fremanezumab	225 mg s.c. every month or 675 mg s.c. every 3 months
Galcanezumab	Start dose 240 mg s.c. followed by 120 mg s.c. every month.
Eptinezumab	100–300 mg i.v. every 3 months

s.c. subcutaneous, i.m. intramuscular, iv. intravenous