Table 1.

The roles of different m6A regulators in CRC

m6A regulators	Genes	Location	Role	Mechanism	Function	Refs
Writers
METTL3	SOX2	mRNA	Oncogene	Stabilize SOX2 mRNA	Promoting CRC tumorigenesis and metastasis	[60]
	MYC	mRNA	Oncogene	Enhance expression of MYC	Promoting CC cells proliferation	[61]
	CCNE1	mRNA	Oncogene	Stabilize CCNE1 mRNA	Promoting CRC cells proliferation	[62]
	HK2/GLUT1	mRNA	Oncogene	Stabilize HK2 and GLUT1 mRNA	Promoting CRC tumorigenesis	[63]
	GLUT1	mRNA	Oncogene	Promote GLUT1 mRNA translation	Promoting CRC development	[64]
	CBX8	mRNA	Oncogene	Stabilize CBX8 mRNA	Promoting CC stemness and chemoresistance	[65]
	SOCS2	mRNA	Oncogene	Degrade SOCS2 mRNA	Promoting CC cells proliferation	[66]
	HSF1	mRNA	Oncogene	Promote HSF1 mRNA translation	Promoting CRC development	[67]
	RP11	lncRNA	Oncogene	Promote the nuclear accumulation of RP11	Promoting CRC cells migration	[68]
	miR-1246	miRNA	Oncogene	Promote miR-1246 maturation	Promoting CRC cells migration and invasion	[69]
	–	–	Tumor suppressor	Decrease the activation of p-p38 and p-ERK	Inhibiting CRC proliferation and migration	[70]
METTL14	SOX4	mRNA	Tumor suppressor	Degrade SOX4 mRNA	Inhibiting CRC metastasis	[71]
	XIST	lncRNA	Tumor suppressor	Mediate the degradation of XIST	Inhibiting CRC tumorigenicity and metastasis	[72]
	miR-375	miRNA	Tumor suppressor	Reduce miR-375 maturation	Inhibiting CRC cell growth, migration	[73]
WTAP	–	–	Oncogene	Promote Wnt signaling pathway	Promoting CC development	[77]
Erasers
FTO	MYC	mRNA	Oncogene	Enhance expression of MYC	Promoting CRC occurrence and progression	[59]
ALKBH5	RP11	lncRNA	Tumor suppressor	Decrease the nuclear accumulation of RP11	Inhibiting CRC cells migration	[68]
Readers
YTHDF1	–	–	Oncogene	Promote Wnt/β-catenin pathway	Promoting CRC cells tumorigenicity	[74]
YTHDF3	GAS5	lncRNA	Oncogene	Facilitate the degradation of GAS5	Promoting CRC progression	[75]
YTHDC1	circNSUN2	circRNA	Oncogene	Facilitate circNSUN2 nuclear export	Promoting CRC cells liver metastasis	[55]
YTHDC2	HIF-1α	mRNA	Oncogene	Stabilize HIF-1α mRNA	Promoting CC cells proliferation	[76]
hnRNPCL2	miR-483,676,877	miRNA	Oncogene	Promote the miRNAs procession	Promoting CRC progression	[78]