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. 2021 Apr 9;22:14. doi: 10.1186/s12863-021-00968-1

Table 5.

Summary of the results of the meta-analysis of the association of APOB gene polymorphisms and hyperlipidemia

SNP Analysis model Genotype model Heterogeneity(I2/P) OR(95%CI) P Publication bias P
APOB MspI A M- vs M+ 0.0%/ 0.731 0.892(0.756 ~ 1.053) 0.178 0.452
D M-M−/M + M- Vs M + M+ 0.0%/0.716 0.868(0.716 ~ 1.053) 0.152 0.707
R M-M-vs M + M−/M + M+ 0.0%/ 0.513 0.932(0.596 ~ 1.456) 0.757 0.908
C M-M- vs M + M+ 0.0%/ 0.555 0.903(0.574 ~ 1.421) 0.660 0.883
M + M- vs M + M+ 0.0%/ 0.654 0.864(0.705 ~ 1.057) 0.156 0.746
APOB XbaI A T vs C 72.4%/ < 0.001 1.444(1.061 ~ 1.966) 0.020 0.732
D TT + CT vs CC 73.5%/ < 0.001 1.360(0.943 ~ 1.962) 0.100 0.945
R TT vs CT + CC 0.0%/ 0.747 1.613(1.022 ~ 2.545) 0.040 0.707
C TT vs CC 0.0%/ 0.774 1.432(0.851 ~ 2.411) 0.017 0.724
CT vs CC 73.5%/ < 0.001 1.322(0.912 ~ 1.917) 0.140 0.837
APOB EcorI A A vs G 70.0%/ < 0.001 1.333(0.942 ~ 1.885) 0.104 0.474
D AA+AG Vs GG 72.9%/ < 0.001 1.366(0.924 ~ 2.020) 0.118 0.283
R AA vs AG + GG 0.0%/ 0.942 1.183(0.628 ~ 2.229) 0.603 0.221
C AA vs GG 0.0%/ 0.886 1.166(0.617 ~ 2.202) 0.637 0.086
AG vs GG 72.6%/ < 0.001 1.356(0.913 ~ 2.015) 0.131 0.371

A allelic model; D dominant model; R recessive model; C codominant model; Publication bias P: using Begg’s or Egger’s tests