Table 2.
Prevalence and density of P. vivax at baseline and endpoint
| Baseline | Endpoint | p value | OR/GMR (95%CI) | |
|---|---|---|---|---|
| Parasite prevalence | ||||
| By microscopy | 43/811 (5%)a | 35/740 (5%)b | 0.643 | 0.89 (0.54–1.44) |
| By PCR | 183/811 (23%) | 135/740 (18%) | 0.038* | 0.77 (0.59–0.99)* |
| By either test | 192/811 (24%) | 142/740 (19%) | 0.035* | 0.77 (0.59–0.98)* |
| Median parasitaemia/µL (IQR) (microscopy) | 112 (48–1000) | 80 (16–1080) | 0.832 | |
| Median 18S copies/µL (IQR) (qPCR) (n baseline = 115, endpoint = 74) | 192.2 (60.6–605.2) | 177.7 (72.7–1535.0) | 0.719 | |
| Gametocyte prevalence | ||||
| By microscopy | 9/811 (1.1%) | 14/740 (1.9%) | 0.215 | 1.72 (0.69–4.53) |
| By pvs25 | 49/744 (7%) | 39/704 (5%) | 0.442 | 0.83 (0.52–1.31) |
| By either test | 49/744 (7%) | 39/704 (5%) | 0.442 | 0.83 (0.52–1.31) |
| Gametocyte density (per μL) | ||||
| By microscopy (median) (IQR) | 160 (28–200) | 64 (32–170) | 0.516 | |
| By pvs25 (geometric mean) (95%CI) | 56.4 (23.8–134.0) | 65.6 (26.5–162.2) | 0.810 | 0.9 (0.2–3.0) |
OR odds ratio, GMR geometric mean ratio
aNine and bseven subjects were not confirmed by PCR during baseline and endpoint, respectively. This is presumably due to degraded DNA and possible LM false positive as 11 of 16 (69%) showed negative microscopy during cross check.
*p < 0.05