Table 2.
Cox regression analysis of variables associated with amputation
| Univariate analysis | P-value | Multivariate analysis | P-value | |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| Age (years) | 1.08 (1.02–1.16) | 0.01 | 1.09 (1.02–1.16) | 0.01 |
| Sex | 1.40 (0.32–6.17) | 0.66 | – | |
| BMI 1 kg/m2 increase | 0.98 (0.88–1.10) | 0.74 | – | |
| SBP 10 mmHg increase | 1.13 (0.86–1.47) | 0.39 | – | |
| DBP 5 mmHg increase | 0.79 (0.63–0.99) | 0.04 | 0.81 (0.64–1.01) | 0.07 |
| LDL-cholesterol 1 mmol/L increase | 1.42 (0.85–2.37) | 0.18 | – | |
| HDL-cholesterol 1 mmol/L increase | 0.67 (0.17–2.63) | 0.56 | – | |
| Current smoking | 1.25 (0.46–3.35) | 0.66 | – | |
| HbA1c (%) | 1.38 (1.11–1.71) | < 0.01 | 1.46 (1.17–1.81) | < 0.01 |
BMI body mass index, DBP diastolic blood pressure, SBP systolic blood pressure, HR hazard ratio, CI confidence interval, LDL low-density lipoprotein, HDL high-density lipoprotein, HbA1c glycated hemoglobin