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. 2021 Apr 8;40:124. doi: 10.1186/s13046-021-01894-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Circ-MBOAT2 absence restrained the process of pancreatic cancer. a The impact of circ-MBOAT2 knockdown on the expression of circ-MBOAT2 was determined by qRT-PCR in PANC-1 and SW1990 cells with β-actin as an internal reference. b-d MTT and cell colony formation assays were employed to reveal the impact of circ-MBOAT2 silencing on the proliferation of PANC-1 and SW1990 cells. e Flow cytometry analysis was performed to illustrate the impact of circ-MBOAT2 knockdown on the apoptosis of PANC-1 and SW1990 cells. f and g The impacts of circ-MBOAT2 downregulation on the invasion and migration of PANC-1 and SW1990 cells were demonstrated by transwell invasion and wound-healing assays, respectively. h-j Glutamine, α-KG and glutamate assay kits were used to detect glutamine consumption, α-KG production and glutamate production, respectively, in PANC-1 and SW1990 cells transfected with si-circ-MBOAT2 or si-NC. **P < 0.01, ***P < 0.001 and ****P < 0.0001