TABLE 5.
The known PD-associated gene enrichment of SIMPO-TSS1500-calculated genes.
| Dataset | Known PD gene source | SIMPO-TSS1500-derived ratio | Background ratio | p-value a |
|---|---|---|---|---|
| GSE111629 | SCG-Drug b | 9.19% (99/1,077) | 7.21% (351/4,868) | 3.26E-03 |
| DisGeNET c | 7.15% (77/1,077) | 5.88% (286/4,868) | 2.79E-02 | |
| GSE72774 | SCG-Drug b | 9.28% (89/959) | 7.21% (351/4,868) | 4.27E-03 |
| DisGeNET c | 7.40% (71/959) | 5.88% (286/4,868) | 1.68E-02 |
a
Calculated by Hypergeometric test.
b
Known PD-associated genes were collected from SCG-Drug (http://zhanglab.hzau.edu.cn/scgdrug).
c
Known PD-associated genes were collected from DisGeNET (http://www.disgenet.org).