Figure 2.

Potential targets for NSC765598. (A) Venn diagram showing common targets of NSC765598 as revealed by the SwissTarget, PASS, and PharmMapper algorithms. Six genes including iNOS, TGFB1, vascular endothelial growth factor receptor 2, FGFR, EDFR, and MAPK2 were predicted by the three algorithms ( Figures 3A, B ), while two genes, viz., signal transducer and activator of transcription and serine/threonine-protein kinase mTOR, were predicted to be top ranked targets of NSC765598 by the two algorithms. (B) Pharmacophore-based models of the six commonly identified NSC765598 target predictions via protein-receptor interactions.