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. 2021 Mar 26;11:656738. doi: 10.3389/fonc.2021.656738

Table 6.

NCI synthetic compounds and standard anticancer agent sharing similar anti-cancer fingerprints and mechanistic correlation with NSC765598.

Rank p CCLC Target NSC Small Molecules MW: (g/mol) Correlation CCLC Standard Anti-cancer
1 0.89 57 758440 Niclosamide (USAN) 327.12 0.42 56 4-ipomeanol
2 0.84 55 50681 N-(2-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide 307.3 0.39 55 Bryostatin 1
3 0.77 54 772889 MK-2048 461.9 0.35 44 Flavoneacetic Acid Ester
4 0.76 57 757391 Dichlorophene 269.1 0.34 55 Tamoxifen
5 0.76 57 37202 Celcot RN 313.3 0.33 56 Rapamycin
6 0.72 55 37188 Azotol OT 277.3 0.33 56 Flavoneacetic Acid
7 0.7 57 37608 Naphthol AS-AN 308.2 0.32 47 Morpholino-ADR
8 0.68 56 777205 3-(4-chloro-2-fluorophenyl)-2H-chromen-2-one 274.6 0.32 44 Spirohydantoin Mustard
9 0.67 57 50686 Naphtanilide TR 311.8 0.31 56 SR2555 (Nitroimidazole)
10 0.67 48 13235 Dibromosalicil 400.0 0.31 53 Piperazine Alkylator
11 0.64 57 766722 3-(1H-benzimidazol-2-yl)-6-hexyl-2-(2-methylphenyl)iminochromen-7-ol 451.6 0.3 57 Rapamycin
12 0.62 57 81947 Dibromsalan (USAN) 3.71.0 0.29 56 Merbarone
13 0.62 56 760057 Nitazoxanide (USAN) 307.2 0.29 46 O6-Methylguanine
14 0.62 52 705084 4-Butanediyldihydroguaiaretic 330.4 0.29 56 DTIC
15 0.61 57 12969 N-(3-Chlorophenyl)-3-hydroxynaphthalene-2-carboxamide 297.7 0.29 56 Fluorodopan

P, Pearson’s correlation coefficient; CCLC, common cell lines count; MW, molecular weight.