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Alpha‐mangostin treatment improves endothelial dysfunction in diabetic mice. A, Aortic aSMase activity of the three groups. B, Aortic ceramide content of the three groups. ACh‐evoked endothelium‐dependent (C) and SNP‐evoked endothelium‐independent (D) vasodilation of aortic segments from diabetic animals treated for 12 weeks with alpha‐mangostin or vehicle. Results are shown as means ± SEM (n = 5‐6). *P < .05 compared to the NC group. #P < .05 compared to the DC group
