FIGURE 3.

H₂S donor lowered Hcy‐induced ER stress in human aortic endothelial cell (HAEC). A, ER stress markers including early markers PDI and GRP78, late markers spliced XBP1 (XBP1s) and cleaved‐caspase 12 (c‐caspase 12) were assayed by Western blot after different concentration of DL‐Hcy (from 25 to 400 μM) treatment for 24 h. B, The ER stress markers change while DL‐Hcy (200 μM) treated HAEC for different times (from 2 to 24 h). C, H₂S donor‐GYY4137 reduced ER stress markers induced by Hcy (200 μM for 24 h)