Grm7−/− and Grm7+/− mice exhibit abnormal social behavior. A, Quantification of time in the chamber with stranger 1 relative to the chamber with the empty cup. B, Quantification of time in the chamber with stranger 2 relative to the chamber with stranger 1. C, Quantification of close interaction time with stranger 1 and empty cup. D, Quantification of close interaction time with stranger 1 and stranger 2. For panels (A) to (D), N = 10 Grm7+/+ (6 female, 4 male), 15 Grm7+/− (10 female, 6 male), 14 Grm7−/− (8 female, 6 male). E, Five-trial social recognition assay. Quantification of interaction time over all trials. F–H, Paired t tests for each genotype comparing trial 4 and trial 5. For panels (E) to (H), N = 10 Grm7+/+ (5 female, 5 male), 11 Grm7+/− (5 female, 6 male), 9 Grm7−/− (5 female, 4 male). *P < .05, **P < .01, ***P < .001, ****P < .0001