Table 1A.
Comparisons across 3 classes in CN
| Variables | No NPS | Depressed/Anxious (Dep/Anx) | Agitated/Irritable (Agit/Irr) | Comparison |
|---|---|---|---|---|
| Class Probability | 0.808 | 0.137 | 0.054 | |
| Age | 74.07 (6.60) | 71.53 (6.60) | 73.75 (6.91) | No NPS > Dep/Anxb |
| Female | 53.3% | 54.0% | 24.4% | No NPS > Agit/Irra Dep/Anx > Agit/Irrb |
| Education | 16.31 (2.71) | 15.92 (2.55) | 16.51 (2.20) | ns |
| ApoE4 positive | 31.0% | 41.9% | 46.7% | No NPS < Dep/Anxc No NPS < Agit/Irrc |
| Cognitive Measures | ||||
| MMSE | 28.87 (1.30) | 28.57 (1.43) | 28.02 (1.50) | No NPS > Agit/Irrb |
| AVLT Long Delay | 7.75 (3.80) | 7.85 (3.65) | 5.89 (3.93) | No NPS > Agit/Irra Dep/Anx > Agit/Irrc |
| AVLT Recognition* | 13.12 (2.17) | 13.53 (2.14) | 12.87 (1.69) | ns |
| Trails A | 34.70 (11.87) | 37.92 (14.32) | 42.00 (14.97) | No NPS < Agit/Irrb |
| Trails B | 85.41 (39.07) | 93.82 (43.42) | 93.71 (27.93) | ns |
| Animals | 20.50 (5.44) | 19.84 (4.95) | 19.22 (5.03) | ns |
| BNT | 27.97 (2.06) | 28.07 (1.76) | 27.49 (1.88) | ns |
| CSF AD Biomarker Profile | ||||
| Aβ positive | 37.3% | 36.2% | 48.6% | ns |
| p-tau positive | 39.3% | 48.3% | 45.7% | ns |
| t-tau positive | 38.9% | 46.6% | 48.6% | ns |
| Aβ × p-tau positive | 17.1% | 24.1% | 22.9% | ns |
| CSF AD Biomarker Measurements | ||||
| Aβ | 1301.80 (637.48) | 1232.45 (507.28) | 1247.69 (649.91) | ns |
| p-tau | 22.14 (9.90) | 25.05 (13.27) | 23.12 (11.64) | ns |
| t-tau | 240.24 (95.77) | 261.63 (113.86) | 245.23 (107.48) | ns |
Notes.
Analyses were based on the most likely class membership assignment. Means and standard deviations are provided for age, years of education, neuropsychological measures, and AD CSF biomarker measurements. Proportions are provided for sex, ApoE4 carrier status, and CSF AD biomarker profiles.
Overall ANOVA model was significant; however, post-hoc analyses revealed no significant differences between classes.
Post-hoc analyses:
Difference between the two classes is significant at p<.001;
Difference between the two classes is significant at p<.01;
Difference between the two classes is significant at p<.05.
CN = cognitively normal; ApoE4 = apolipoprotein E-ε4; MMSE = Mini-Mental State Examination; AVLT = Rey Auditory Verbal Learning Test; Trails A = Trail Making Test A; Trails B = Trail Making Test B; BNT = Boston Naming Test; CSF = cerebrospinal fluid; AD = Alzheimer’s disease; Aβ = amyloid beta; p-tau = phosphorylated tau; t-tau = total tau; ns = not significant