Table 1B.
Comparisons across classes in MCI
| Variables | No NPS | Depressed/Irritable (Dep/Irr) | Complex | Comparison |
|---|---|---|---|---|
| Class Probability | 0.627 | 0.334 | 0.039 | |
| Age | 73.22 (7.30) | 73.38 (7.53) | 71.05 (7.70) | ns |
| Female | 40.8% | 28.6% | 37.5% | No NPS > Dep/Irra |
| Education | 15.93 (2.91) | 15.92 (2.79) | 15.00 (3.00) | ns |
| ApoE4 positive | 50.1% | 57.8% | 62.5% | ns |
| Cognitive Measures | ||||
| MMSE | 27.29 (1.86) | 27.50 (1.81) | 27.08 (1.95) | ns |
| AVLT Long Delay | 2.38 (2.62) | 2.26 (2.57) | 2.29 (2.85) | ns |
| AVLT Recognition | 9.33 (3.88) | 9.33 (3.04) | 8.79 (4.53) | ns |
| Trails A | 42.93 (21.43) | 43.70 (20.34) | 41.21 (25.47) | ns |
| Trails B | 122.23 (72.02) | 139.36 (75.51) | 128.71 (72.66) | No NPS < Dep/Irrb |
| Animals | 16.03 (4.73) | 15.73 (4.41) | 15.92 (4.62) | ns |
| BNT | 27.75 (4.33) | 25.51 (4.06) | 25.63 (3.95) | ns |
| CSF AD Biomarker Profile | ||||
| Aβ positive | 65.2% | 74.7% | 58.8% | ns |
| p-tau positive | 61.4% | 65.3% | 52.9% | ns |
| t-tau positive | 58.0% | 62.0% | 52.9% | ns |
| Aβ × p-tau positive | 49.2% | 55.3% | 47.1% | ns |
| CSF AD Biomarker Measurements | ||||
| Aβ | 975.41 (541.24) | 873.98 (500.16) | 1075.72 (583.04) | ns |
| p-tau | 29.38 (16.55) | 29.63 (14.17) | 28.79 (16.44) | ns |
| t-tau | 301.69 (149.24) | 300.21 (124.80) | 297.24 (148.65) | ns |
Notes.
Analyses were based on the most likely class membership assignment. Means and standard deviations are provided for age, years of education, neuropsychological measures, and CSF AD biomarker measurements. Proportions are provided for sex, ApoE4 carrier status, and CSF AD biomarker profiles.
Post-hoc analyses:
Difference between the two classes is significant at p<.001;
Difference between the two classes is significant at p<.05.
MCI = mild cognitive impairment; ApoE4 = apolipoprotein E-ε4; MMSE = Mini-Mental State Examination; AVLT = Rey Auditory Verbal Learning Test; Trails A = Trail Making Test A; Trails B = Trail Making Test B; BNT = Boston Naming Test; CSF = cerebrospinal fluid; AD = Alzheimer’s disease; Aβ = amyloid beta; p-tau = phosphorylated tau; t-tau = total tau; ns = not significant