Behavioral abnormalities in the DM. a Aberrant locomotor activity. b Increased immobility in the forced swim test. c Deficits in sociability in the social interaction test. d Impaired visual memory in the novelty preference test. CTL wild-type mice without adolescent isolation, DM DISC1 mutant mice exposed to a 3-week period of isolation. N = 13–17 for a, N = 20 for b, N = 13–17 for c and d. Values are means ± SE. Statistical differences were determined using a two-way ANOVA with repeated measures (group, F(1, 28) = 68.15, P < 0.05 for a), and the t test for b to d (*P < 0.05)