TABLE 4.

Comparison of the Clinical Utility of Each NIT at High and Low Cutoff Points for Advanced Fibrosis in NAFLD

High cutoff point	NIT	Sensitivity	Specificity	FP	FN	PPV	NPV	Accuracy
Diabetes absence	FIB‐4 index > 2.67	0.657	0.877	0.123	0.343	0.404	0.953	0.852
	NFS > 0.675	0.286	0.989	0.011	0.714	0.769	0.916	0.913
	APRI > 2.0	0.114	0.964	0.036	0.886	0.286	0.896	0.865
	COL4‐7S > 5.9	0.686	0.899	0.101	0.314	0.462	0.958	0.875
Diabetes presence	FIB‐4 index > 2.67	0.537	0.856	0.144	0.463	0.439	0.898	0.797
	NFS > 0.675	0.426	0.891	0.109	0.574	0.451	0.881	0.813
	APRI > 2.0	0.278	0.957	0.043	0.722	0.577	0.863	0.842
	COL4‐7S > 5.9	0.685	0.872	0.128	0.315	0.529	0.929	0.839
Low cutoff point
Diabetes absence	FIB‐4 index > 1.30	0.971	0.547	0.453	0.029	0.214	0.993	0.595
	NFS > $‐$1.45	0.771	0.685	0.315	0.229	0.237	0.959	0.695
	APRI > 0.5	1.00	0.362	0.638	0	0.166	1.000	0.434
	COL4‐7S > 4.8	0.886	0.725	0.275	0.114	0.290	0.980	0.743
Diabetes presence	FIB‐4 index > 1.30	0.889	0.475	0.525	0.111	0.262	0.953	0.547
	NFS > $‐$1.45	0.926	0.358	0.642	0.074	0.233	0.958	0.457
	APRI > 0.5	0.944	0.327	0.673	0.056	0.228	0.966	0.434
	COL4‐7S > 4.8	0.889	0.689	0.311	0.111	0.375	0.967	0.723

Abbreviations: FN, false negative; FP, false positive; NPV, negative predictive value; PPV, positive predictive value.