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. 2021 Mar 8;49(6):3338–3353. doi: 10.1093/nar/gkab141

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Schematic representation of chromosome end structures that were reconstructed by one-way replication of TALT (Template for ALT) and telomeric repeats (not to scale). All subtelomeres were intact and short telomeric repeats remained at the junctions between a subtelomeric region and a TALT copy. (A) The origin of the TALT1 (upper), typical telomere structure in the reference genome (middle) and new telomere structure of the Caenorhabditis elegans ALT1 and ALT2 survivor lines (lower). The original TALT1 (blue bar) is located in the right arm of chromosome V and consists of a 1446-bp genomic sequence flanked by short telomeric repeats (grey bars) (B) Assembled and confirmed TALT1-mediated chromosome end structures in the ALT1 and ALT2 lines. (C) The origin of the TALT2 (upper), typical telomere structure in the reference genome (middle) and new telomere structure of the ALT3 and ALT4 survivor lines (lower). The original TALT2 (red bar) is located in the far left subtelomeric region of chromosome I and consists of a 135-bp genomic sequence flanked by short telomeric repeats (gray bars). (D) Assembled and confirmed TALT2-mediated chromosome end structures in the ALT3 and ALT4 survivor lines.