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Model for chromosome end repair or reconstruction processes after telomere dysfunction. (A) Simple inter-chromosomal fusion between subtelomere-deleted chromosome ends. (B) Break-Fusion-Bridge (BFB) cycle followed by inter-chromosomal fusion. Black arrows represent the orientation of the broken, discontinuous fragments. (C) ALT-mediated chromosome end reconstruction. Short remaining telomeric repeats may facilitate the replication of TALTs and telomeric repeats to the new ends.
