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DNMT1 and UHRF1, key actors of DNA methylation maintenance. (A) Domain architecture and interactors of DNMT1 (top) and UHRF1 (bottom). Bidirectional black arrows indicate interactions. Green arrows show enzymatic modification. Lilac arrows denote inhibitory interactions. (B) Several pathways have been shown to permit DNMT1 recruitment. Additional pathways may remain to be discovered. It is not yet clear which modes of recruitment predominate in different situations.
