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. 2021 Feb 28;49(6):3077–3091. doi: 10.1093/nar/gkab094

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — (A) Heatmap of experimental contact probability matrix. (B) Heatmap of simulated (filtered) Hi–C contact probability matrix. The matrix has been obtained by averaging over the ensemble of Hi–C matrices calculated for each G , namely G= 3.6, G= 1.8 and G = 1.0. (C) Heatmap of difference between contact probability matrix (simulated – experimental matrix), negative number or blue color indicates higher probability value in experimental matrix and positive number or red color indicates higher probability in simulated matrix. The regions of maximum divergence (encircled pink off-diagonal arms) appear near location of oriCs and difs and may be due to the presence of replication forks. (D) Distribution of absolute differences between the two contact probability matrices(experimental and simulated).