Skip to main content
. Author manuscript; available in PMC: 2021 Apr 9.
Published in final edited form as: Nature. 2020 Aug 27;586(7830):560–566. doi: 10.1038/s41586-020-2708-8

Extended Data 1: SARS-CoV-2 infection in HFH4-hACE2 transgenic mice.

Extended Data 1:

Male and female HFH4-hACE2 mice were infected with 105 PFU SARS-CoV-2 WT. (A) Percent starting weight. Dotted line represents weight loss criteria for humane euthanasia. n=2 mock and 5 SARS-CoV-2. (B) Survival. (C–D) Lung (C) and brain (D) viral titer. Dotted line represents limit of detection (LOD). Undetected samples are plotted at half the LOD. ‘x’ symbol indicates mice that succumbed to infection. 2dpi: n=2; 5dpi: n=5. (E–F) Whole body plethysmography assessing pulmonary function for PenH (E) and Rpef (F).