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. 2021 Apr 9;7(15):eabg1950. doi: 10.1126/sciadv.abg1950

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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

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Fig. 6 — The potency and specificity of the LMO2 Abd compounds was evaluated in dose-response BRET assays. (A to C) In BRET assays, Abd-L9, Abd-L10, Abd-L16, and Abd-L22 compounds were assessed in dose inhibition responses for (A) LMO2-iDAb LMO2_dm3, (B) LMO2-LDB1, and (C) LMO2-iDAb LMO2 (unmutated iDAb) BRET interactions. (D) Dose-response assays of Abd-L15, Abd-L17, Abd-L18, and Abd-L19 with LMO2-iDAb LMO2_dm3, LMO2-LDB1, and LMO2-iDAb LMO2 BRET interactions. Each experiment was performed twice. Error bars presented in (A) to (D) correspond to mean values ± SD of biological repeats.