Table 2. Significantly enriched signaling pathways and dysregulated genes.

Pathway	FDR	Up_genes	Down_genes
TNF signaling pathway	4.25E–08	–	Fas, Creb5, Gm5431, Jun, Lif, Junb, Fos, Ptgs2, Cxcl1, Vcam1, Ccl2, Mmp9
IL-17 signaling pathway	4.88E–06	–	Mapk15, Fosl1, Il17c, Jun, Fos, Ptgs2, Cxcl1, Ccl2, Mmp9
MAPK signaling pathway	2.34E–02	Hspa1l	Fas, Jun, Dusp6, Dusp1, Nr4a1, Fos, Areg, Epha2
ErbB signaling pathway	3.09E–02	–	Jun, Nrg1, Areg, Hbegf
NF-kappa B signaling pathway	4.11E–02	Blnk	Ptgs2, Vcam1, Plau