Table 2. Risk of outcomes within 90 days after minor stroke or TIA by glucose metabolism status.
Outcomes | Non-DM | PDDM | NDDM-RH | Stress hyperglycemia |
Stroke | ||||
Events, n (%) | 151 (7.1) | 80 (13.1) | 39 (17.3) | 29 (46.8) |
Adjusted HR (95% CI)* | Ref | 1.85 (1.41-2.43) | 2.61 (1.83-3.71) | 9.97 (6.68-14.88) |
Adjusted HR (95% CI)# | Ref | 1.81 (1.38-2.39) | 2.51 (1.76-3.59) | 9.66 (6.39-14.59) |
Adjusted HR (95% CI)* | 0.54 (0.41-0.71) | Ref | 1.41 (0.96-2.07) | 5.39 (3.51-8.28) |
Adjusted HR (95% CI)# | 0.55 (0.42-0.73) | Ref | 1.39 (0.94-2.04) | 5.32 (3.43-8.26) |
Ischemic stroke | ||||
Events, n (%) | 147 (6.9) | 78 (12.8) | 39 (17.3) | 29 (46.8) |
Adjusted HR (95% CI)* | Ref | 1.85 (1.41-2.44) | 2.68 (1.88-3.81) | 10.18 (6.82-15.20) |
Adjusted HR (95% CI)# | Ref | 1.81 (1.37-2.40) | 2.60 (1.82-3.71) | 9.96 (6.59-15.06) |
Adjusted HR (95% CI)* | 0.54 (0.41-0.71) | Ref | 1.45 (0.98-2.12) | 5.50 (3.57-8.47) |
Adjusted HR (95% CI)# | 0.55 (0.42-0.73) | Ref | 1.43 (0.97-2.12) | 5.50 (3.54-8.54) |
Composite events‡ | ||||
Events, n (%) | 151 (7.1) | 81 (13.3) | 40 (17.8) | 29 (46.8) |
Adjusted HR (95% CI)* | Ref | 1.88 (1.43-2.46) | 2.69 (1.89-3.81) | 9.97 (6.68-14.87) |
Adjusted HR (95% CI)# | Ref | 1.84 (1.40-2.43) | 2.59 (1.82-3.69) | 9.66 (6.39-14.58) |
Adjusted HR (95% CI)* | 0.53 (0.41-0.70) | Ref | 1.43 (0.98-2.09) | 5.31 (3.46-8.15) |
Adjusted HR (95% CI)# | 0.54 (0.41-0.72) | Ref | 1.41 (0.96-2.06) | 5.24 (3.38-8.13) |
Any bleeding | ||||
Events, n (%) | 43 (2.0) | 14 (2.3) | 1 (0.4) | 1 (1.6) |
Adjusted HR (95% CI)* | Ref | 1.13 (0.62-2.08) | 0.24 (0.03-1.71) | 1.40 (0.19-10.17) |
Adjusted HR (95% CI)# | Ref | 1.28 (0.68-2.39) | 0.26 (0.04-1.93) | 1.57 (0.21-11.65) |
Adjusted HR (95% CI)* | 0.88 (0.48-1.62) | Ref | 0.21 (0.03-1.59) | 1.23 (0.16-9.43) |
Adjusted HR (95% CI)# | 0.78(0.42-1.46) | Ref | 0.21 (0.03-1.58) | 1.23 (0.16-9.53) |
Abbreviations: non-DM, non-diabetes mellitus; PDDM, previously diagnosed diabetes mellitus; NDDM-RH, newly diagnosed diabetes mellitus-related hyperglycemia; hs-CRP: high-sensitive C-reactive protein. *adjusted for age and sex. #adjusted for age, sex, body mass index, hs-CRP, history of ischemic stroke, TIA, myocardial infarction, known atrial fibrillation or flutter, angina, valvular heart disease, hypertension and hypercholesterolemia, smoking status, NIHSS score on admission, qualifying events of minor stroke or TIA, randomized treatment of aspirin alone or clopidogrel plus aspirin, use of antihypertensive medications, and statin medications. ‡Composite events: stroke, myocardial infarction, or death from cardiovascular causes.