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. 2021 Mar 25;13(6):7781–7799. doi: 10.18632/aging.202875

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Copyright: © 2021 Hendee et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Endothelial Twist1 mediates age-dependent inhibition of post-PNX compensatory lung growth. (A) Graphs showing the ratio of the weight of right lung cardiac lobe to mouse BW in the 2M vs. 24M old Twist1^fl/fl or Twist1^fl/fl/Tie2-cre mice after PNX (n=6, mean ± s.e.m., *, p<0.05). (B) H&E-stained mouse lungs in the cardiac lobe of 2M vs. 24M old Twist1^fl/fl or Twist1^fl/fl/Tie2-cre mice after PNX (top, 3^rd) Scale bar, 25 μm. IF micrographs showing staining of CD31, VEGFR2 and DAPI in 2M vs. 24M old Twist1^fl/fl or Twist1^fl/fl/Tie2-cre mice after PNX (2^nd, bottom). Scale bar, 100 μm. (C) Graph showing integrated density of VEGFR2 in 2M vs. 24M old Twist1^fl/fl or Twist1^fl/fl/Tie2-cre mice after PNX (n=5-6, mean ± s.e.m., *, p<0.05). (D) Graph showing the mRNA levels of Vegfr2 in the ECs isolated from 2M vs. 24M old Twist1^fl/fl or Twist1^fl/fl/Tie2-cre mouse lungs after PNX (n=5, mean ± s.e.m., *, p<0.05).