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. 2021 Mar 21;13(6):7998–8025. doi: 10.18632/aging.202852

Table 1B. Comparative transcriptomic analyses between bat, human, mouse.

Gene Bat Human Mouse
PIK3CA 0.483 -0.233 -0.568
ROCK1 0.468 -0.091 -0.41
RB1CC1 0.446 -0.143 -0.164
CSNK2A1 0.415 -0.015 -0.406
NEDD4 0.383 -0.043 -0.1
PAFAH1B2 0.293 -0.278 -0.097
USP33 0.278 -0.237 -0.165
TRAPPC8 0.274 -0.167 -0.066
ULK2 0.271 -0.017 -0.312
SIRT1 0.243 -0.091 -0.566
SNX14 0.214 -0.27 -0.158
VTA1 0.208 -0.302 -0.327
MAP3K7 0.203 -0.213 -0.247
TBK1 0.198 -0.218 -0.215
VPS36 0.179 -0.207 -0.483
NRBF2 0.177 -0.236 -0.361
DNM1L 0.168 -0.081 -0.245
UBXN2B 0.146 -0.14 -0.179
EIF2AK4 0.141 -0.069 -0.361
SH3GLB1 0.132 -0.149 -0.039
PIK3R4 0.11 -0.227 -0.457
ATP6V1H 0.099 -0.172 -0.032
PIK3C3 0.077 -0.268 -0.269
RAB3GAP1 0.053 -0.013 -0.567
ATP6V1C1 0.03 -0.186 -0.09
U2AF1 0.03 -0.053 -0.207

(A) Comparison of the pathway expression pattern for autophagy-associated GO terms. Within each species, the median of the Spearman’s correlation coefficients of all genes under each of enriched age-associated GO terms was used to represent their overall expression pattern with age. The values behind the GO terms indicate the number of genes enriched. (B) The autophagy associated genes that exhibited the opposite direction of expression changes with age in bat compared to human and mouse are shown. Values indicate the Spearman’s correlation coefficients between gene expression and age for each species.