Table 4. Serum inflammatory response in excision wound model mice treated with vehicle and BCOP on day 4, 8, 12 and 16.
| DAY 4 | DAY 8 | DAY 12 | DAY 16 | |||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
| The level of IL-8 (pg/L) | ||||||||
| NC | 50.16 | 7.88 | 47.42 | 6.39 | 59.77 | 9.44 | 47.56 | 8.49 |
| BCOP-L | 74.86* | 10.9 | 86.07* | 4.70 | 79.16* | 6.66 | 65.68* | 11.75 |
| BCOP-M | 101.16* | 6.82 | 82.42* | 8.05 | 87.14* | 8.6 | 108.76* | 8.86 |
| BCOP-H | 89.01* | 8.67 | 112.48* | 8.60 | 93.30* | 11.24 | 92.69* | 7.00 |
| The level of IL-10 (pg/mL) | ||||||||
| NC | 467.06 | 58.82 | 413.71 | 72.52 | 368.09 | 48.56 | 395.54 | 50.09 |
| BCOP-L | 734.99* | 48.56 | 569.36* | 32.72 | 514.99* | 61.87 | 488.09* | 62.32 |
| BCOP-M | 761.16* | 64.16 | 559.42* | 70.00 | 560.72* | 50.02 | 532.57* | 38.78 |
| BCOP-H | 700.02* | 61.46 | 711.89* | 66.69 | 682.82* | 48.51 | 742.23* | 47.56 |
| The level of TNF-α (ng/L) | ||||||||
| NC | 369.64 | 60.6 | 342.92 | 47.18 | 278.77 | 39.76 | 320.62 | 56.7 |
| BCOP-L | 453.33* | 56.6 | 425.05* | 47.34 | 411.37* | 24.24 | 389.01* | 49.29 |
| BCOP-M | 563.44* | 59.38 | 552.41 | 56.18 | 423.96* | 41.19 | 519.25* | 43.99 |
| BCOP-H | 675.38* | 42.73 | 507.78* | 34.44 | 639.03* | 42.17 | 452.60* | 40.75 |
| The level of CCL2 (pg/ml) | ||||||||
| NC | 984.14 | 86.45 | 889.24 | 92.75 | 867.29 | 127.84 | 932.04 | 135.03 |
| BCOP-L | 1175.68* | 107.28 | 1327.49* | 137.24 | 1244.69* | 138.66 | 1016.32 | 145.88 |
| BCOP-M | 1724.06* | 121.32 | 1570.65* | 80.99 | 1454.34* | 116.87 | 1228.95* | 145.19 |
| BCOP-H | 1676.09* | 78.78 | 1466.55* | 69.96 | 1551.52* | 110.85 | 1474.52* | 120.02 |
| The level of SDF-1α (ng/L) | ||||||||
| NC | 155.72 | 22.37 | 176.29 | 19.89 | 178.02 | 23.59 | 142.22 | 21.71 |
| BCOP-L | 251.13* | 23.73 | 253.29* | 19.45 | 237.87* | 22.73 | 217.01* | 25.75 |
| BCOP-M | 259.40* | 16.38 | 271.53* | 23.25 | 312.73* | 24.87 | 321.12* | 27.93 |
| BCOP-H | 273.41* | 21.49 | 327.74* | 22.45 | 365.18* | 30.21 | 354.57* | 27.85 |
Values were presented as mean ± SD. * Compared with the NC, statistical significance was set at p < 0.05. NC, normal control group; BCOP-L, 0.75 g/kg bovine bone collagen oligopeptides group; BCOP-M, 1.50 g/kg bovine bone collagen oligopeptides group; BCOP-H, 3.00 g/kg bovine bone collagen oligopeptides group.